The Real Difference Between LDL & HDL: Apo A1 & Apo B

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Many cholesterol tests include fractionation and details re: Apo A1 and Apo B. What are they? We cover these items in the video. Apo A1 is the protein that makes up all HDL family lipoproteins. Apo B is the protein that makes up all the other basic lipoprotein families, including LDL, VLDL, IDL, and Chylomicrons. HDL stands for High Density Lipprotein. LDL stands for Low Density Lipoprtein. VLDL stands for Very Low Density Lipoprotein. And IDL stands for Intermediate Density Lipoprotein. Chylomicrons are the largest and fluffiest of the lipoprotein families, made up almost entirely of Apo B and cholesterol, not other fats or oils.

Dr. Brewer started as an Emergency Doctor. After seeing too many preventable heart attacks, he went to Johns Hopkins to learn Preventive Medicine. While there, he went on the run the post-graduate training program (residency) in Preventive Medicine. From there, he made a career of practicing and managing preventive medicine and primary care clinics. His later role in this area was Chief Medical Officer for Premise, which has close to 1,000 primary care/prevention clinics. He was also the Chief Medical Officer for MDLIVE, the second largest telemedicine company. More recently, he founded PrevMed, a heart attack, and stroke prevention clinic.

At PrevMed, we focus on heart attack, stroke, and cognitive decline. We serve patients who have already experienced an event as well as those who have not developed a diagnosis or event. Dr. Brewer provides services via telemedicine or in person if you’re in the Lexington, KY area. We find a lot of undiagnosed Pre-Diabetes or Insulin Resistance. Treating unrecognized risk factors like Pre-Diabetes allows reduction of risk and prevention of disease.

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6 Responses

  1. westfield90 says:

    An awesome educational video as always. Thank you Doctor!

  2. Mark O'Meara says:

    Non HDL equals ApoB yes?

  3. Joseph H says:

    So how do you treat it if either one (or both) is high?

  4. xxx xxx says:

    8:50 Wow, this is an eye opener. I didn't even know that Apo(A1) could be harmful too. 😕

  5. Richard Lund says:

    Thanks for helping educate us. I have heard Ron Krauss talk about why the higher ApoB number (directly correlating to the number of particles) and the background to it is related to the reduced ability of the smaller LDL particles to bind to liver cells to deliver their remaining contents into those cells. This results in the small particles being in circulation longer and thereby continuing to expose the arteries to potential damage. Any thoughts?

  6. Joe A7Rii says:

    My ratio dropped to .24 now from .51 in March. You’re guidance made all the difference.! Thank You Dr. Brewer

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