RATOL PASTE side effects in tamil | medical awareness in Tamil



#ratolpaste # #freeradical explanation in tamil

Poisoning is a major problem globally and its incidence is rising
due to rapid industrialization and urbanization. The exact incidence of acute
poisoning is not known in India because of lack of any central poison
registry. The toxins involved in acute poisoning cases vary from place to
place. In western countries, the commonest toxins are medicinal agents. In
contrast, in India, insecticide, pesticides and rodenticide are the most
commonly consumed agents in adults.
Ratol is a rodenticide (rat killer paste) ,it contains yellow phosphorus,
a severe local and systemic toxin causing damage to gastrointestinal, hepatic,
cardiovascular, and renal systems. Among these liver is the most commonly
affected organ and acute liver failure with coagulopathy is the most dreaded
complication. Other fatal complications are acute tubular necrosis, hepatorenal syndrome, hypotension and arrhythmias.
Clinical manifestations of yellow phosphorous poisoning has three
stages. First stage has gastrointestinal symptoms like nausea and vomiting in
the absence of any laboratory abnormalities. Second stage occurs after 24–
48 hours characterised by rising transaminases, although the patient may be
asymptomatic. In some cases, this progresses to the third stage characterised
by acute liver failure with coagulopathy and encephalopathy, which can be
fatal.
RODENTICIDE
Rodenticides for many years have been an important cause of
significant morbidity and mortality in patients who present to an emergency
room with deliberate self harm.
An annual incidence of 500,000 cases has been reported. . One recent
study shows Incidence of hospital admission of rodenticide poison in
tamilnadu is approximately 9%.
LETHAL DOSE
More than 1mg/kg
MECHANISM OF ACTION
YP is a protoplasmic poison ,it causes multi organ damage due to
uncoupling of oxidative phosphorylation
After ingestion YP is rapidly absorbed through the intestinal tract and
phosphorous remains stable in the gut for longer period because it has more
water content and low oxygen tension . After absorbtion 69% to 73% of the total
ingested dose concentrates in the liver , some amount of YP reaches the brain,
striated muscle, and the kidneys also. peak level is reached 2 to 3 hours after of
toxic oral ingestion.so liver is most vulnerable organ to damages occur.
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Yellow phosphorous

Phosphoric acid

Exothermic reaction

Direct tissue damage due to production of free radicals
CLINICAL MANIFESTATION
The course of events following yellow phosphorus poisoning has three
stages.
FIRST STAGE: (first 24 hours)
May be asymptomatic or
Burning pain in the throat and abdomen
Nausea ,vomiting diarrhoea and severe abdominal pain
Laboratory values are normal .
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SECOND STAGE : STAGE OF HEPATITIS (24 TO 48 HOURS)
Patient may be asymptomatic.
AST & ALT are elevated
Haematological abnormalities are present
THIRD STAGE : STAGE OF ACUTE LIVER FAILURE
Only few cases are progresses to the third stage
Systemic toxicities are present
GASTROINTESTINAL SYSTEM
Prolonged vomiting and diarrhoea
Features of acute fulminant hepatic failure
Liver tenderness and enlargement
Hematemesis and melena due to coagulopathy
Jaundice and pruritus
Hepatorenal syndrome
Marked elevation of transamiases, alkaline phosphatases and
prothrombin time
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RENAL SYSTEM
Acute tubular necrosis
Acute renal failure
CARDIOVASCULAR SYSTEM
Hypotension and tachycardia
Arrhythmias
Acute pulmonary edema
Myocardial injury
Cardiogenic shock
Alteration in ECG such as inverted T waves, changes in QRS complex,
tachycardia, arrhythmias and decreased ventricular contractility has been
reported
HEAMATOLOGICAL
Direct bone marrow suppression mainly selective myeloid series
suppression causes leucopenia with preserved normoblastic erythroid
maturation, normal megakaryocytes, lymphocytes, and plasma cells
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CENTRAL NERVOUS SYSTEM
Confusion
Psychosis
Hallucinations
Coma free radicals google
#medicalawarenessintamil

source: https://dinhk.net/

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20 Responses

  1. straw berry says:

    En relation oru ponnu tday death.ithe.rate poison saptu.dubaile saptu..Ange one mnth achu.iniki mrg death ayitanga.ipo dead body inge Trichy kondu varanga…enaku rompa kastama iruku.😭😭😭

  2. saran kumar says:

    Enaku therinchu na itha check pani parthuten yethuvum agala na sapitu one week achu ipo varaiku nrmlah ta iruken nenga sona mathiri yethuvum agalaiye sir

  3. M Ishabella says:

    Enoda frd rat killer cake oru peace saptaru alcohol vera kudichurunthanga athu onnum agathunu avare soltraru hospital poga matranga yethavathu agumaa avaru saptu 6 hours aguthu bt oru symptoms yethume illa

  4. Mani Krish says:

    Is there not a quick way to die???

  5. Kavin Kumar says:

    Payama iruku sir 🙉

  6. Yamini Sudharsun says:

    Sir,i took this before 2 years..but got complete treatment and then I got discharged from hospital..tell me whether any issues will raise in futures..I took 4 pumbs from the tube

  7. Ammu Kutty says:

    Pls rly me nanum konjam than sapten Enna aagum

  8. Hepron Hepron says:

    ratol ini vara kudathu atha thadai panunga sir please 🙏😭

  9. Reeta Jebamalar says:

    Dr ponnaatharam use pannalaama plzzzzzzzzzzzzzzzzzzzzzzzzz reply suddenly….. Me

  10. Yamuna duraisamy says:

    Sir vanakkam…nan rat killer paste eduthu 17 days unconscious ku poyi pilaichu vandhen..but ipo memory loss padhatram…ellame varudhu alavuku meeri…pls side effects sollungalen…future il enna agum…liver transplantation panra alavuku poyi piragu kadavul arulal transplantation nadakama pilaithen…pls enaku sollunga…polaichu vandhum ennal mudhal madhiri iyalba velai seiyamudiyala…

  11. Muruganandham u says:

    Sir monocrotophos and dimethoate effect pathi explain pannunga

  12. linga Lingaa says:

    Iam ready for dead

  13. Mano karthikeyan says:

    Sir unga numper kudunga sir pls

  14. Hepron Hepron says:

    Nan sapdu 2days achu but onnu akala sir

  15. Hepron Hepron says:

    Nan sapdu 2days achu but onnu akala sir

  16. bad boy says:

    pesticide toxicology tamil video series create pannuga

  17. mani vishnu says:

    Sir konjama I.e one drop level or u 3days sap ta on um Agatha ….illa time edukuma…..reply pannuga pls

  18. Riya Riya says:

    100% true sir

  19. JEYANATHEN MARIA GUVANALLA S says:

    Useful …👏👏👏

  20. aarthika mahendran says:

    Informative sir👏👏

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